Candesartan Cilexetil → Isoamyl Acetate

HRID 640734

Reaktionsgleichung

Reaktionsgleichung von HRID 640734
CCOC1N(CC2C=CC(C3C=CC=CC=3C3N=NNN=3)=CC=2)C2[C:10]([C:31]([O:33][CH:34]([O:36]C(OC3CCCCC3)=O)[CH3:35])=O)=[CH:9][CH:8]=CC=2N=1.[CH2:46](Cl)Cl>>[C:34]([O:33][CH2:31][CH2:10][CH:9]([CH3:8])[CH3:46])(=[O:36])[CH3:35]

Komponenten

3

Edukt 2

HCID 2540Candesartan CilexetilHCID 6344Dichloromethane

Produkt 1

HCID 31276Isoamyl Acetate

Versuchsvorschrift

Candesartan cilexetil Form I (C) (2.5 g) was dissolved in DCM (3.5 ml) at about 25° C. to form a solution, and isoamyl acetate (35 ml) was added dropwise. The solution was cooled in an ice bath and stirred for about 3 hours to obtain a precipitate. The precipitate was collected by filtration and dried under reduced pressure (30 mbar) at 50° C. for about 7.5 hours to obtain Form XIII.

Quellen und Nachweise

ORD-Eintrag
ord-9a989835fb294537858d698b573f4d39
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07692023B2

Verknüpfte Notizen

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