1-Piperidineacetic acid, ethyl ester → Piperidin-1-yl-acetic acid

HRID 64075

Reaktionsgleichung

Reaktionsgleichung von HRID 64075
[N:1]1([CH2:7][C:8]([O:10]CC)=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1>Cl>[N:1]1([CH2:7][C:8]([OH:10])=[O:9])[CH2:6][CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

3

Edukt 1

HCID 6434661-Piperidineacetic acid, ethyl ester

Produkt 1

HCID 201097Piperidin-1-yl-acetic acidAusbeute 60 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

The solution of ethyl 2-(piperidin-1-yl)acetate (2.4 g, 14.0 mmol, 1.0 eq) in 8 N HCl was stirred at 95° C. for 16 h. The mixture was concentrated on vacuum pump and quenched and extracted as in Intermediate Example 15(b). The solvent was distilled off to afford the product in 60% yield (1.2 g). LC-MS (ESI): Calculated mass: 143.1; Observed mass 144.4 [M+H]+ (rt: 0.21 min).

Aufarbeitung

  1. concentrationThe mixture was concentrated on vacuum pump
  2. customquenched
  3. extractionextracted as in Intermediate Example 15(b)
  4. distillationThe solvent was distilled off
  5. customto afford the product in 60% yield (1.2 g)
  6. customObserved mass 144.4 [M+H]+ (rt: 0.21 min)

Quellen und Nachweise

ORD-Eintrag
ord-fa250c7a410a424eb9b5d41a75fb6808
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447091B2

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