1-Pyrrolidineacetic acid, ethyl ester → Pyrrolidin-1-ylacetic acid

HRID 64078

Reaktionsgleichung

Reaktionsgleichung von HRID 64078
[N:1]1([CH2:6][C:7]([O:9]CC)=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1>Cl>[N:1]1([CH2:6][C:7]([OH:9])=[O:8])[CH2:5][CH2:4][CH2:3][CH2:2]1

Komponenten

3

Edukt 1

HCID 2109961-Pyrrolidineacetic acid, ethyl ester

Produkt 1

HCID 414564Pyrrolidin-1-ylacetic acidAusbeute 54 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 313Hydrochloric AcidLösungsmittel

Versuchsvorschrift

The solution of ethyl 2-(pyrrolidin-1-yl)acetate (1.8 g, 11.95 mmol, 1.0 eq) in 8 N HCl was stirred at 95° C. for 16 h. The mixture was concentrated on vacuum pump and quenched and extracted as in Intermediate Example 15(b). The solvent was distilled off to afford the product in 54% yield (1.4 g). LC-MS (ESI): Calculated mass: 129.1; Observed mass 130.1 [M+H]+ (rt: 0.26 min).

Aufarbeitung

  1. concentrationThe mixture was concentrated on vacuum pump
  2. customquenched
  3. extractionextracted as in Intermediate Example 15(b)
  4. distillationThe solvent was distilled off
  5. customto afford the product in 54% yield (1.4 g)
  6. customObserved mass 130.1 [M+H]+ (rt: 0.26 min)

Quellen und Nachweise

ORD-Eintrag
ord-51539287a7fb4cb9b67dc53ad3804551
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447091B2

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