Potassium Carbonate → HCID 79362010, Verbindung

HRID 64079Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 64079
[Br:1][C:2]1[CH:3]=[N:4][NH:5][CH:6]=1.C([O-])([O-])=O.[K+].[K+].Br[CH2:14][CH2:15][C:16]([CH3:19])([OH:18])[CH3:17]>CN(C=O)C>[Br:1][C:2]1[CH:3]=[N:4][N:5]([CH2:14][CH2:15][C:16]([CH3:19])([OH:18])[CH3:17])[CH:6]=1

Komponenten

5

Edukt 3

HCID 11430Potassium CarbonateHCID 163754-BromopyrazoleHCID 106071724-Bromo-2-methylbutan-2-ol

Produkt 1

HCID 79362010HCID 79362010, VerbindungAusbeute 60 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

To a solution of 4-bromo-1H-pyrazole (1 g, 6.84 mmol, 1.0 eq) in DMF were added K2CO3 (2.3 g, 17.1 mmol, 2.5 eq.) and 4-bromo-2-methylbutan-2-ol (1.7 g, 10.27 mmol, 1.5 eq.). The mixture was stirred at RT for 16 h. The mixture was quenched and extracted as in Intermediate Example 5(a). The solvent was distilled off to afford the product in 60% yield (0.9 g). LC-MS (ESI): Calculated mass 233.0; Observed mass 235.0. [M+H]+ (rt: 0.64 min).

Aufarbeitung

  1. customThe mixture was quenched
  2. extractionextracted as in Intermediate Example 5(a)
  3. distillationThe solvent was distilled off
  4. customto afford the product in 60% yield (0.9 g)
  5. custom[M+H]+ (rt: 0.64 min)

Quellen und Nachweise

ORD-Eintrag
ord-5ef8ce30534a4941887a18ee3f3b4646
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447091B2

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