Sodium Hydroxide → 4-(4-(1-(5-amino-2',4'-difluorobiphenyl-3-yl)-1H-benzo[d]imidazol-5-yl)-1H-1,2,3-triazol-1-yl)-2-methylbutan-2-ol

HRID 64098Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 64098
[F:1][C:2]1[CH:7]=[C:6]([F:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[C:13]([N:15]2[C:19]3[CH:20]=[CH:21][C:22]([C:24]4[N:25]=[N:26][N:27]([CH2:29][CH2:30][C:31]([OH:34])([CH3:33])[CH3:32])[CH:28]=4)=[CH:23][C:18]=3[N:17]=[CH:16]2)[CH:12]=[C:11]([NH:35]C(=O)C)[CH:10]=1.[OH-].[Na+]>C(O)C>[NH2:35][C:11]1[CH:12]=[C:13]([N:15]2[C:19]3[CH:20]=[CH:21][C:22]([C:24]4[N:25]=[N:26][N:27]([CH2:29][CH2:30][C:31]([CH3:33])([OH:34])[CH3:32])[CH:28]=4)=[CH:23][C:18]=3[N:17]=[CH:16]2)[CH:14]=[C:9]([C:3]2[CH:4]=[CH:5][C:6]([F:8])=[CH:7][C:2]=2[F:1])[CH:10]=1

Komponenten

4

Edukt 2

HCID 14798Sodium HydroxideHCID 89501332N-(2',4'-difluoro-5-(5-(1-(3-hydroxy-3-methylbutyl)-1H-1,2,3-triazol-4-yl)-1H-benzo[d]imidazol-1-yl)biphenyl-3-yl)acetamide

Produkt 1

HCID 1177779384-(4-(1-(5-amino-2',4'-difluorobiphenyl-3-yl)-1H-benzo[d]imidazol-5-yl)-1H-1,2,3-triazol-1-yl)-2-methylbutan-2-olAusbeute 38 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 702EthanolLösungsmittel

Reaktionsbedingungen

Temperatur
90 °C

Versuchsvorschrift

To a solution of the compound of Example 44 (400 mg, 0.77 mmol) in ethanol (20 ml) was added aqueous solution of NaOH (385 mg, 9.63 mmol, 12.5 eq.) and the mixture was heated at 90° C. for 3 h. The mixture was quenched and extracted as in Example 1(d). The solvent was distilled off to give the product in 38% yield (140 mg).

Aufarbeitung

  1. customThe mixture was quenched
  2. extractionextracted as in Example 1(d)
  3. distillationThe solvent was distilled off
  4. customto give the product in 38% yield (140 mg)

Quellen und Nachweise

ORD-Eintrag
ord-8243a5016ee2402c8fa11bd45173a00b
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447091B2

Notizen zur Reaktion

Wird geladen…