Glycolic Acid → Benzyl 2-hydroxyacetate

HRID 6412

Reaktionsgleichung

Reaktionsgleichung von HRID 6412
[CH2:1](C(O)C(O)=O)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:13]([OH:17])(=[O:16])[CH2:14][OH:15].C(N(CC1C=CC=CC=1)C(=NC(C)C)O)(C)C>C1COCC1>[C:13]([O:17][CH2:1][C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1)(=[O:16])[CH2:14][OH:15]

Komponenten

5

Edukt 3

HCID 757Glycolic AcidHCID 3848(+-)-3-Phenyllactic acidHCID 178418581HCID 178418581, Verbindung

Produkt 1

HCID 561337Benzyl 2-hydroxyacetate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Reaktionsbedingungen

Temperatur
-15 °C

Versuchsvorschrift

Construction of Benzyl-glycolic Acid. Glycolic acid (7.69,100 mmols) is added to N,N'-diisopropylbenzylisourea (23.39,100 mmols) with stirring for 1 hour. The volume is then increased to 200 mL with THF, and the mixture stirred for 48 h at room temperature. After cooling the mixture to -15° C., the diisopropylurea is removed by filtration and the THF evaporated under reduced pressure. The resulting product is pumped under high vacuum for 24 h to give benzyl glycolate which may be used without further purification.

Aufarbeitung

  1. stirringthe mixture stirred for 48 h at room temperature
  2. customthe diisopropylurea is removed by filtration
  3. customthe THF evaporated under reduced pressure
  4. waitThe resulting product is pumped under high vacuum for 24 h

Quellen und Nachweise

ORD-Eintrag
ord-5c317f14cf624df39c513f9852247f2b
Quelldatensatz
uspto-grants-1993_09
Patentnummer
US05248761

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