Ethanol → 6-methyl-3-(2H-1,2,3-triazol-2-yl)picolinic acid

HRID 64200

Reaktionsgleichung

Reaktionsgleichung von HRID 64200
[CH3:1][C:2]1[N:7]=C(C#N)[C:5]([N:10]2[N:14]=[CH:13][CH:12]=[N:11]2)=[CH:4][CH:3]=1.[OH-:15].[Na+].[CH3:17][CH2:18][OH:19]>>[CH3:1][C:2]1[N:7]=[C:17]([C:18]([OH:15])=[O:19])[C:5]([N:10]2[N:14]=[CH:13][CH:12]=[N:11]2)=[CH:4][CH:3]=1

Komponenten

4

Edukt 3

HCID 702EthanolHCID 14798Sodium HydroxideHCID 68281582HCID 68281582, Verbindung

Produkt 1

HCID 593637336-methyl-3-(2H-1,2,3-triazol-2-yl)picolinic acid

Reaktionsbedingungen

Temperatur
100 °C

Versuchsvorschrift

To a solution of the title compound of Step A (730 mg, 4 mmol) in EtOH (10 mL) was added 4 N NaOH (1 mL, 4 mmol). The mixture was heated at 100° C. for 24 h. The reaction mixture was concentrated in vacuo to a white solid which was used without further purification in subsequent steps. MS (ESI) mass calcd. for C9H8N4O2, 204.1. m/z found 205.1 [M+H]+.

Aufarbeitung

  1. concentrationThe reaction mixture was concentrated in vacuo to a white solid which
  2. customwas used without further purification in subsequent steps

Quellen und Nachweise

ORD-Eintrag
ord-a6fc142842d84e73accb3ea2282c7394
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447117B2

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