Hydrochloric Acid → HCID 131732523, Verbindung
Reaktionsgleichung
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][C@H:9]2[C@@H:14]3[CH2:15][C@@H:11]([CH2:12][N:13]3C(OC(C)(C)C)=O)[CH2:10]2)=[N:6][CH:7]=1.Cl>CCOC(C)=O.O1CCOCC1>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:8][C@H:9]2[C@@H:14]3[CH2:15][C@@H:11]([CH2:12][NH:13]3)[CH2:10]2)=[N:6][CH:7]=1Komponenten
5
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 2
Versuchsvorschrift
xHCl. To the title compound of step A (149 mg, 0.0404 mmol) in EtOAc (1.5 mL) was added 4M HCl in dioxane (5 mL). After 3.25 h, the reaction was concentrated to give the title compound of step B (128 mg) which was used without further purification. MS (ESI) mass calcd. for C11H13BrN2O, 268.0. m/z found 269.0 [M+H]+.
Aufarbeitung
- concentrationthe reaction was concentrated
Quellen und Nachweise
- ORD-Eintrag
- ord-b57bba83be514faf9e5ed96238ed525e
- Quelldatensatz
- uspto-grants-2016_09
- Patentnummer
- US09447117B2
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