Ethyl 2-((tert-butoxycarbonyl)amino)acetate → 4-Bromo-2-[(tert-butoxycarbonyl-ethoxycarbonylmethyl-amino)-methyl]-5-(4-fluoro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrrole-3-carboxylic acid ethyl ester

HRID 642232Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 642232
[CH2:1]([O:3][C:4]([C:6]1[C:10]([Br:11])=[C:9]([C:12]2[CH:17]=[CH:16][C:15]([F:18])=[CH:14][CH:13]=2)[N:8]([C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=2)[C:7]=1[CH2:27]Br)=[O:5])[CH3:2].[CH2:29]([O:31][C:32](=[O:42])[CH2:33][NH:34][C:35]([O:37][C:38]([CH3:41])([CH3:40])[CH3:39])=[O:36])[CH3:30]>>[CH2:1]([O:3][C:4]([C:6]1[C:10]([Br:11])=[C:9]([C:12]2[CH:13]=[CH:14][C:15]([F:18])=[CH:16][CH:17]=2)[N:8]([C:19]2[CH:24]=[CH:23][C:22]([O:25][CH3:26])=[CH:21][CH:20]=2)[C:7]=1[CH2:27][N:34]([C:35]([O:37][C:38]([CH3:39])([CH3:41])[CH3:40])=[O:36])[CH2:33][C:32]([O:31][CH2:29][CH3:30])=[O:42])=[O:5])[CH3:2]

Komponenten

3

Edukt 2

HCID 357729Ethyl 2-((tert-butoxycarbonyl)amino)acetateHCID 684263014-Bromo-2-bromomethyl-5-(4-fluoro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrrole-3-carboxylic acid ethyl ester

Produkt 1

HCID 684268754-Bromo-2-[(tert-butoxycarbonyl-ethoxycarbonylmethyl-amino)-methyl]-5-(4-fluoro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrrole-3-carboxylic acid ethyl ester

Versuchsvorschrift

Prepared in analogy to that of Example 1(c) from 4-bromo-2-bromomethyl-5-(4-fluoro-phenyl)-1-(4-methoxy-phenyl)-1H-pyrrole-3-carboxylic acid ethyl ester and tert-butoxycarbonylamino-acetic acid ethyl ester. The title compound, ESI MS (m/z): 655 (M+Na+).

Quellen und Nachweise

ORD-Eintrag
ord-082b38c093604dcbb0d3a0ec2023902a
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07696223B2

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