Acetyl chloride → HCID 86613188, Verbindung
Reaktionsgleichung
[C:1]([CH2:4][C:5]1[C:13]2[C:8](=[CH:9][CH:10]=[C:11]([F:14])[CH:12]=2)[N:7]([CH2:15][C:16]2[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:19]=[CH:18][CH:17]=2)C=1C(O)=O)([OH:3])=[O:2].[C:29](Cl)(=[O:31])[CH3:30]>>[F:14][C:11]1[CH:12]=[C:13]2[C:8](=[CH:9][CH:10]=1)[N:7]([CH2:15][C:16]1[C:25]3[C:20](=[CH:21][CH:22]=[CH:23][CH:24]=3)[CH:19]=[CH:18][CH:17]=1)[C:30]1[C:29](=[O:31])[O:3][C:1](=[O:2])[CH2:4][C:5]2=1Komponenten
3
Versuchsvorschrift
A mixture of 3-carboxymethyl-5-fluoro-1-naphthalen-1-ylmethyl-1H-indole-2-carboxylic acid (from Example 33, 0.5 g) in acetylchloride (6.2 ml) was heated to reflux for 5 h. The solution was evaporated and the residue triturated with diethylether to give 6-fluoro-9-naphthalen-1-ylmethyl-4,9-dihydro-pyrano[3,4-b]indole-1,3-dione as a pale yellow solid. MS: 377.4 ([M+NH4]+).
Aufarbeitung
- temperaturewas heated
- temperatureto reflux for 5 h
- customThe solution was evaporated
- customthe residue triturated with diethylether