1-(Bromomethyl)naphthalene → 4-naphthalen-1-ylmethyl-4H-thieno[3,2-b]pyrrole-5-carboxylic acid methyl ester

HRID 642730Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 642730
[S:1]1[C:8]2[CH:7]=[C:6]([C:9]([O:11][CH3:12])=[O:10])[NH:5][C:4]=2[CH:3]=[CH:2]1.Br[CH2:14][C:15]1[C:24]2[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=2)[CH:18]=[CH:17][CH:16]=1>>[CH3:12][O:11][C:9]([C:6]1[N:5]([CH2:14][C:15]2[C:24]3[C:19](=[CH:20][CH:21]=[CH:22][CH:23]=3)[CH:18]=[CH:17][CH:16]=2)[C:4]2[CH:3]=[CH:2][S:1][C:8]=2[CH:7]=1)=[O:10]

Komponenten

3

Edukt 2

HCID 1378441-(Bromomethyl)naphthaleneHCID 4058811methyl 4H-thieno[3,2-b]pyrrole-5-carboxylate

Produkt 1

HCID 685784874-naphthalen-1-ylmethyl-4H-thieno[3,2-b]pyrrole-5-carboxylic acid methyl ester

Versuchsvorschrift

Using general procedure B, methyl 4H-thieno[3,2-b]pyrrole-5-carboxylate was coupled with 1-bromomethyl-naphthalene to give 4-naphthalen-1-ylmethyl-4H-thieno[3,2-b]pyrrole-5-carboxylic acid methyl ester which was hydrolyzed as described in the general procedure B (Exp. 2.2) to give the title compound as a white solid. MS: 306.3 ([M−H]−).

Quellen und Nachweise

ORD-Eintrag
ord-77771ddaf6bb485991ef4cb668cb3351
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07696240B2

Notizen zur Reaktion

Wird geladen…