Phosphorus tribromide → 4-(Bromomethyl)-2-chloro-3-methylbenzonitrile

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

To a solution of compound 7B (700 mg, 3.9 mmol) in CH2Cl2 (15 mL) was added PBr3 (5.8 mL, 5.8 mmol, 1N in CH2Cl2) at −15° C., and stirred at −15° C. for 3 hr. The reaction was slowly quenched with saturated NaHCO3 solution at −15° C.

Herkunft & Nachweise