HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
3-(azidomethyl)-1-(4-iodophenyl)-1H-pyrazole → (1-(4-iodophenyl)-1H-pyrazol-3-yl)methanamine
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | 3-(azidomethyl)-1-(4-iodophenyl)-1H-pyrazole | HCID 86614009 | — |
| Katalysator | Nickel | HCID 935 | — |
| Lösungsmittel | Methanol | HCID 887 | — |
| Produkt | (1-(4-iodophenyl)-1H-pyrazol-3-yl)methanamine | HCID 65805535 | 84,1% |
Reaktionsschritte
A mixture of 3-(azidomethyl)-1-(4-iodophenyl)-1H-pyrazole (100 mg, 0.31 mmol) and Ra—Ni (50% aq. slurry, 150 mg) in MeOH (8 mL) was hydrogenated under balloon H2 for 3 hrs. It was filtered through celite. The filtrate was concentrated in vacuo to give (1-(4-iodophenyl)-1H-pyrazol-3-yl)methanamine (78 mg).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07696352B2 |
| Quelldatensatz | uspto-grants-2010_04 |
| ORD ID | ord-a56343b3dbb74dd782d128e53a759453 |
| Quellennotiz | uspto-grants-2010_04 |