Hydrochloric Acid → Phthalylglycine aldehyde

HRID 643074

Reaktionsgleichung

Reaktionsgleichung von HRID 643074
C(O[C:4]1([O:14]CC)[NH:8][C:7](=[O:9])[C:6]2=[CH:10][CH:11]=[CH:12][CH:13]=[C:5]12)C.Cl.[O:18]1CC[CH2:20][CH2:19]1>>[O:14]=[C:4]1[C:5]2[C:6](=[CH:10][CH:11]=[CH:12][CH:13]=2)[C:7](=[O:9])[N:8]1[CH2:20][CH:19]=[O:18]

Komponenten

4

Edukt 3

HCID 313Hydrochloric AcidHCID 8028TetrahydrofuranHCID 66899166Phthalimide diethylacetal

Produkt 1

HCID 76201Phthalylglycine aldehyde

Reaktionsbedingungen

Temperatur
75 °C

Versuchsvorschrift

To a solution of phthalimide diethylacetal (15 g) in tetrahydrofuran (THF) (30 mL) was added 10% aqueous HCl (18 mL). After heating at 75° C. for 5 hrs, the solution was allowed to cool to room temperature, and ethyl acetate was separated and dried over magnesium sulfate (MgSO4). The solution was filtered and evaporated to provide 11.2 g of the titled compound.

Aufarbeitung

  1. temperatureto cool to room temperature
  2. customethyl acetate was separated
  3. dry with materialdried over magnesium sulfate (MgSO4)
  4. filtrationThe solution was filtered
  5. customevaporated

Quellen und Nachweise

ORD-Eintrag
ord-d36663426f704177947eda52ba39cdbd
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07696226B2

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