Methyl iodide → 5-Pyrimidinecarboxylic acid, 4-amino-2-(methylthio)-, ethyl ester

HRID 643685

Reaktionsgleichung

Reaktionsgleichung von HRID 643685
I[CH3:2].[NH2:3][C:4]1[C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:8][N:7]=[C:6]([SH:15])[N:5]=1>CN(C)C=O>[NH2:3][C:4]1[C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:8][N:7]=[C:6]([S:15][CH3:2])[N:5]=1

Komponenten

4

Edukt 2

HCID 6328Methyl iodideHCID 178469867HCID 178469867, Verbindung

Produkt 1

HCID 2226665-Pyrimidinecarboxylic acid, 4-amino-2-(methylthio)-, ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

Iodomethane (2.6 g, 18 mmol) was added to the hot solution (˜50° C.) of ethyl 4-amino-2-mercaptopyrimidine-5-carboxylate (3.0 g, 15 mmol) in N,N-dimethylformamide (150 mL) and stirred at room temperature for 20 min. Solvent was removed in vacuo and the solid residue was washed by water. After dried in vacuo, desired product was obtained as a white solid (3.1 g, 97%).

Aufarbeitung

  1. customSolvent was removed in vacuo
  2. washthe solid residue was washed by water
  3. customAfter dried in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-53fa3e6a94484237aa6b32775fcfe148
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07700622B2

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