Methyl iodide → 5-Pyrimidinecarboxylic acid, 4-amino-2-(methylthio)-, ethyl ester
Reaktionsgleichung
I[CH3:2].[NH2:3][C:4]1[C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:8][N:7]=[C:6]([SH:15])[N:5]=1>CN(C)C=O>[NH2:3][C:4]1[C:9]([C:10]([O:12][CH2:13][CH3:14])=[O:11])=[CH:8][N:7]=[C:6]([S:15][CH3:2])[N:5]=1Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
Iodomethane (2.6 g, 18 mmol) was added to the hot solution (˜50° C.) of ethyl 4-amino-2-mercaptopyrimidine-5-carboxylate (3.0 g, 15 mmol) in N,N-dimethylformamide (150 mL) and stirred at room temperature for 20 min. Solvent was removed in vacuo and the solid residue was washed by water. After dried in vacuo, desired product was obtained as a white solid (3.1 g, 97%).
Aufarbeitung
- customSolvent was removed in vacuo
- washthe solid residue was washed by water
- customAfter dried in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-53fa3e6a94484237aa6b32775fcfe148
- Quelldatensatz
- uspto-grants-2010_04
- Patentnummer
- US07700622B2
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