5,6,7,8-Tetrahydro-2-naphthol → 1-Bromo-5,6,7,8-tetrahydro-2-naphthalenol
Reaktionsgleichung
[CH:1]1[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][C:2]=1[OH:11].C1C(=O)N([Br:19])C(=O)C1>CN(C=O)C>[Br:19][C:1]1[C:10]2[CH2:9][CH2:8][CH2:7][CH2:6][C:5]=2[CH:4]=[CH:3][C:2]=1[OH:11]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
To a solution of 5,6,7,8-tetrahydro-2-naphthol (2.50 g, 16.9 mmol) in DMF (5 mL), is added dropswise NBS (3.0 g, 16.9 mmol). The solution is stirred at room temperature for 18 h. The mixture is washed with water, extracted with CH2Cl2, dried over MgSO4 and concentrated. The crude material is purified via Biotage, eluting with 5-40% EtOAc/hexanes to afford 1-bromo-5,6,7,8-tetrahydronaphthalen-2-ol.
Aufarbeitung
- washThe mixture is washed with water
- extractionextracted with CH2Cl2
- dry with materialdried over MgSO4
- concentrationconcentrated
- customThe crude material is purified via Biotage
- washeluting with 5-40% EtOAc/hexanes
Quellen und Nachweise
- ORD-Eintrag
- ord-1ebb5123b4644fd49450b46042036ffb
- Quelldatensatz
- uspto-grants-2010_04
- Patentnummer
- US07700633B2
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