Dimethylformamide → HCID 178434462, Verbindung

HRID 643976Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 643976
[Li]C(C)(C)C.Br[C:7]1[CH:8]=[C:9]2[C:15]([CH3:16])=[N:14][NH:13][C:10]2=[N:11][CH:12]=1.CN([CH:20]=[O:21])C>C1COCC1>[CH3:16][C:15]1[C:9]2[C:10](=[N:11][CH:12]=[C:7]([CH:20]=[O:21])[CH:8]=2)[NH:13][N:14]=1

Komponenten

5

Edukt 3

HCID 6228DimethylformamideHCID 178418306HCID 178418306, VerbindungHCID 178434433HCID 178434433, Verbindung

Produkt 1

HCID 178434462HCID 178434462, VerbindungAusbeute 20,5 %

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

80 ml anhydrous THF were charged into a 250 ml round bottom flask and was chilled to −78° C. t-BuLi (1.70 M in THF, 17.6 ml, 30 mmol) was added to the flask via syringe. After stirring for 5 min, 5-bromo-3-methyl-1H-pyrazolo[3,4-b]pyridine (2.12 g, 10 mmol) was added dropwise via syringe. After 30 min, DMF (3.65 g, 50 mmol) in 20 ml THF was added dropwise and the mixture was stirred for overnight. The reaction was quenched by saturated aqueous ammonium chloride. After evaporating the excess THF, the reaction mixture was extracted by ethylacetate twice. The combined organic layer was washed with brine once and dried over sodium sulfate. The crude product was chromatographed with 50% ethylacetate in hexane to afford the desired product (0.23 g, y=20.5%).

Aufarbeitung

  1. additionwas added to the flask via syringe
  2. waitAfter 30 min
  3. stirringthe mixture was stirred for overnight
  4. customThe reaction was quenched by saturated aqueous ammonium chloride
  5. customAfter evaporating the excess THF
  6. extractionthe reaction mixture was extracted by ethylacetate twice
  7. washThe combined organic layer was washed with brine once
  8. dry with materialdried over sodium sulfate
  9. customThe crude product was chromatographed with 50% ethylacetate in hexane

Quellen und Nachweise

ORD-Eintrag
ord-81548312bb9a4418a7d6fc4913a9d59d
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07700636B2

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