Citric Acid → 2-[2-(1-tert-Butoxycarbonylpiperidin-4-yloxy)-4-(3-hydroxy-pyrrolidin-1-yl)benzoylamino]-N-(5-chloropyridin-2-yl)benzamide

Beteiligte Stoffe

Reaktionsschritte

Using methods substantially equivalent to those described in example 4-F except that the workup used saturated aqueous citric acid instead of water, 2-[2-(1-tert-butoxy-carbonylpiperidin-4-yloxy)-4-(3-hydroxypyrrolidin-1-yl)benzoylamino]-N-(5-chhloro-pyridin-2-yl)benzamide (160 mg, 0.25 mmol, 47%) was prepared from 2-[4-fluoro-2-(1-tert-butoxycarbonylpiperidin-4-yloxy)benzoylamino]-N-(5-chloropyridin-2-yl)-benzamide and 3-hydroxypyrrolidine.

Herkunft & Nachweise