Methyl 4-fluorosalicylate → Methyl 4-fluoro-2-(3-tert-butoxycarbonylaminopropoxy)benzoate
Reaktionsgleichung
[OH:1][C:2]1[CH:11]=[C:10]([F:12])[CH:9]=[CH:8][C:3]=1[C:4]([O:6][CH3:7])=[O:5].[C:13]([O:17][C:18]([NH:20][CH2:21][CH2:22][CH2:23]O)=[O:19])([CH3:16])([CH3:15])[CH3:14]>>[F:12][C:10]1[CH:9]=[CH:8][C:3]([C:4]([O:6][CH3:7])=[O:5])=[C:2]([O:1][CH2:23][CH2:22][CH2:21][NH:20][C:18]([O:17][C:13]([CH3:14])([CH3:16])[CH3:15])=[O:19])[CH:11]=1Komponenten
3
Versuchsvorschrift
Using a procedure analogous to Example 1-C, methyl 2-hydroxy-4-fluorobenzoate and 3-(tert-butoxycarbonylamino)propanol gave the desired product as a white solid (20.6 g, 84%). 1NMR IS-MS, m/e: 328 (m+1).
Quellen und Nachweise
- ORD-Eintrag
- ord-7703097fe671402eb56334e383416ee3
- Quelldatensatz
- uspto-grants-2010_04