tert-Butyl 3-(hydroxymethyl)piperidine-1-carboxylate → Methyl 2-(1-tert-butoxycarbonylpiperidin-3-ylmethoxy)-4-tert-butylbenzoate
Reaktionsgleichung
[C:1]([C:5]1[CH:14]=[CH:13][C:8]([C:9]([O:11][CH3:12])=[O:10])=[C:7]([OH:15])[CH:6]=1)([CH3:4])([CH3:3])[CH3:2].[C:16]([N:23]1[CH2:28][CH2:27][CH2:26][CH:25]([CH2:29]O)[CH2:24]1)([O:18][C:19]([CH3:22])([CH3:21])[CH3:20])=[O:17]>>[C:19]([O:18][C:16]([N:23]1[CH2:28][CH2:27][CH2:26][CH:25]([CH2:29][O:15][C:7]2[CH:6]=[C:5]([C:1]([CH3:4])([CH3:2])[CH3:3])[CH:14]=[CH:13][C:8]=2[C:9]([O:11][CH3:12])=[O:10])[CH2:24]1)=[O:17])([CH3:22])([CH3:20])[CH3:21]Komponenten
3
Versuchsvorschrift
In a manner substantially equivalent to Example 21-C, methyl 4-tert-butyl-2-hydroxybezoate (2.08 g, 10.0 mmol) and 1-Boc-3-hydroxymethylpiperidine (2.15 g, 10.0 mmol) were reacted to give the desired product (1.30 g, 32.1%).
Quellen und Nachweise
- ORD-Eintrag
- ord-1873bcee984d44faad1cfff66b577b01
- Quelldatensatz
- uspto-grants-2010_04