Hexane → 5-Bromo-4-tert-butyl-1,3-thiazol-2-amine

2-Amino-4-[(1,1-dimethyl)ethyl]thiazole (compound of Example 181(1); 0.87 g, 5.6 mmol) was dissolved in carbon tetrachloride (9 mL). N-Bromosuccinimide (1.00 g, 5.6 mmol) was added, and the mixture was stirred at room temperature for 1 hour. Hexane was added to the reaction mixture. The insoluble matter was filtered off, and the residue obtained by evaporation of the filtrate under reduced pressure was purified by chromatography on silica gel (hexane:ethyl acetate=2:1) to give the title compound (1.23 g, 93.7%) as an yellowish gray powder.

1. filtrationThe insoluble matter was filtered off
2. customthe residue obtained by evaporation of the filtrate under reduced pressure
3. customwas purified by chromatography on silica gel (hexane:ethyl acetate=2:1)

ORD-Eintrag

ord-7a79036d05b44beabd86e65881402ec7

Quelldatensatz

uspto-grants-2010_04

DOI

10.6084/m9.figshare.5104873.v1

Patentnummer

US07700655B2