HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
HRID 64459Erstellt: 23. Oktober 2026
Cyclopentanemethanol → N-[(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-phenylethyl]-8-(cyclopentylmethoxy)-2-methylimidazo[1,2-a]pyridine-3-carboxamide
https://huagongshe.com/de/reaction/64459
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|
| Edukt | Cyclopentanemethanol | HCID 77195 | — |
| Edukt | Cyanomethylenetributylphosphorane | HCID 4622928 | — |
| Edukt | N-[(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-phenylethyl]-8-hydroxy-2-methylimidazo[1,2-a]pyridine-3-carboxamide | HCID 86713409 | — |
| Lösungsmittel | Toluene | HCID 1140 | — |
| Produkt | N-[(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-phenylethyl]-8-(cyclopentylmethoxy)-2-methylimidazo[1,2-a]pyridine-3-carboxamide | HCID 86713474 | — |
Reaktionsschritte
A mixture of 120 mg of N-[(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-phenylethyl]-8-hydroxy-2-methylimidazo[1,2-a]pyridine-3-carboxamide, 60 μl of cyclopentylmethanol, 156 μl of (tributylphosphoranylidene)acetonitrile, and 2.4 ml of toluene was stirred at 110° C. for 16 hours, followed by purification using silica gel chromatography, to obtain 100 mg of N-[(1R)-2-{[tert-butyl(dimethyl)silyl]oxy}-1-phenylethyl]-8-(cyclopentylmethoxy)-2-methylimidazo[1,2-a]pyridine-3-carboxamide.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
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| Patentnummer | US09447090B2 |
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| Quelldatensatz | uspto-grants-2016_09 |
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| ORD ID | ord-5ab65197b73f4c0aac187c473560d72d |
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| Quellennotiz | uspto-grants-2016_09 |
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