Hydrogen Bromide → Isoindolin-5-ol HCl
Reaktionsgleichung
C[O:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[CH2:8][NH:7][CH2:6]2.[BrH:12]>>[BrH:12].[OH:2][C:3]1[CH:4]=[C:5]2[C:9](=[CH:10][CH:11]=1)[CH2:8][NH:7][CH2:6]2Komponenten
3
Versuchsvorschrift
5-Methoxyisoindoline (8.34 g, 55.97 mmol) in 48% aqueous hydrobromic acid (100 ml) was stirred and held at reflux for 16 hours. Upon cooling to room temperature the solvent was removed in vacuo to afford 5-hydroxyisoindoline hydrobromide (11.32 g, 93%) as a tan solid. 1H NMR (DMSO-d6) 9.63 (1H, br s), 9.32 (2H, br s), 7.18 (1H, d), 6.79 (1H, d), 6.76 (1H, dd), 4.42 (2H, t), 4.38 (2H, t). MS: [M+H]+ 136.
Aufarbeitung
- temperatureat reflux for 16 hours
- customwas removed in vacuo
Quellen und Nachweise
- ORD-Eintrag
- ord-e03d7e101e884e48b4f77e24dedc5d7a
- Quelldatensatz
- uspto-grants-2010_04
- Patentnummer
- US07700625B2
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