Octanal → 2-Benzoyl-dec-2-enoic acid ethyl ester

HRID 64505

Reaktionsgleichung

Reaktionsgleichung von HRID 64505
N1CCCCC1.[CH:7](=O)[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14].[C:16]([CH2:24][C:25]([O:27][CH2:28][CH3:29])=[O:26])(=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1>C(OC)(C)(C)C>[CH2:28]([O:27][C:25](=[O:26])[C:24]([C:16](=[O:23])[C:17]1[CH:22]=[CH:21][CH:20]=[CH:19][CH:18]=1)=[CH:7][CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH3:14])[CH3:29]

Komponenten

5

Edukt 3

HCID 454OctanalHCID 7170Ethyl benzoylacetateHCID 8082Piperidine

Produkt 1

HCID 688401452-Benzoyl-dec-2-enoic acid ethyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 15413tert-Butyl methyl etherLösungsmittel

Versuchsvorschrift

Piperidine (0.10 ml, 0.5 mol %) is added to a mixture of octanal (25.6 g, 0.20 mol) and ethyl benzoylacetate (38.4 g, 0.20 mol) at 5° C. The resulting solution is warmed to room temperature and stirred for 24 h, during which a fine emulsion is formed. The mixture is diluted with methyl t-butyl ether and the organic layer washed with 2 N aq. HCl-solution, water and brine, then dried over MgSO4.

Aufarbeitung

  1. customis formed
  2. washthe organic layer washed with 2 N aq. HCl-solution, water and brine
  3. dry with materialdried over MgSO4

Quellen und Nachweise

ORD-Eintrag
ord-d130adbbc50d4bb7b96cde2778db0c2d
Quelldatensatz
uspto-grants-2016_09
Patentnummer
US09447364B2

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