Hydrochloric Acid → 4-(3,3-Difluoropyrrolidin-1-yl)piperidine hydrochloride

HRID 645475Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 645475
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([N:14]2[CH2:18][CH2:17][C:16]([F:20])([F:19])[CH2:15]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:21]>O1CCOCC1>[ClH:21].[F:20][C:16]1([F:19])[CH2:17][CH2:18][N:14]([CH:11]2[CH2:10][CH2:9][NH:8][CH2:13][CH2:12]2)[CH2:15]1

Komponenten

4

Edukt 2

HCID 313Hydrochloric AcidHCID 53419023Tert-butyl 4-(3,3-difluoropyrrolidin-1-YL)piperidine-1-carboxylate

Produkt 1

HCID 687110244-(3,3-Difluoropyrrolidin-1-yl)piperidine hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 312751,4-DioxaneLösungsmittel

Versuchsvorschrift

4-(3,3-difluoro-pyrrolidin-1-yl)-piperidine-1-carboxylic acid tert-butyl ester (1.77 mmol) is treated with 4N HCl in 1,4-dioxane (6 mL) and stirred at room temperature for 1 h. The reaction mixture is concentrated in vacuo and the resulting residue is used for the next step without further purification.

Aufarbeitung

  1. concentrationThe reaction mixture is concentrated in vacuo
  2. customthe resulting residue is used for the next step without further purification

Quellen und Nachweise

ORD-Eintrag
ord-a13adcd5765b4148a72afbf3d1f3fbc3
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07704996B2

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