1-(2-Methanesulfonylethyl)piperazine dihydrochloride → cis-[4,5-Bis-(4-chloro-phenyl)-2-(2-ethoxy-pyridin-3-yl)-4,5-dihydro-imidazol-1-yl]-[4-(2-methanesulfonyl-ethyl)-piperazin-1-yl]-methanone

Beteiligte Stoffe

Rolle	Name	HCID	Einwaage
Edukt	1-(2-Methanesulfonylethyl)piperazine dihydrochloride	HCID 17749885	—
Edukt	4,5-Bis-(4-chloro-phenyl)-2-(2-ethoxy-pyridin-3-yl)-4,5-dihydro-imidazole-1-carbonyl chloride	HCID 86613622	—
Produkt	cis-[4,5-Bis-(4-chloro-phenyl)-2-(2-ethoxy-pyridin-3-yl)-4,5-dihydro-imidazol-1-yl]-[4-(2-methanesulfonyl-ethyl)-piperazin-1-yl]-methanone	HCID 24774798	—

Reaktionsschritte

4,5-Bis-(4-chloro-phenyl)-2-(2-ethoxy-pyridin-3-yl)-4,5-dihydro-imidazole-1-carbonyl chloride (example 1) was reacted with 1-(2-methanesulfonylethyl)piperazine dihydrochloride to give cis-[4,5-bis-(4-chloro-phenyl)-2-(2-ethoxy-pyridin-3-yl)-4,5-dihydro-imidazol-1-yl]-[4-(2-methanesulfonyl-ethyl)-piperazin-1-yl]-methanone in an analogous manner as described in example 1. HR-MS (ES, m/z) calculated for C30H34N5O4SCl2 [(M+H)+] 630.1703, observed 603.1705.

Herkunft & Nachweise

DOI	10.6084/m9.figshare.5104873.v1
Patentnummer	US07705007B2
Quelldatensatz	uspto-grants-2010_04
ORD ID	ord-7def2ca2311f4b8d9edc6121c083234b
Quellennotiz	uspto-grants-2010_04