Pyridine → Allyl 2-[4-(2-quinoxalinyloxy)phenoxy]propanoate

HRID 64579

Reaktionsgleichung

Reaktionsgleichung von HRID 64579
[CH2:1]([OH:4])[CH:2]=[CH2:3].N1C=CC=CC=1.[N:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[N:14]=[CH:13][C:12]=1[O:21][C:22]1[CH:33]=[CH:32][C:25]([O:26][CH:27]([CH3:31])[C:28](Cl)=[O:29])=[CH:24][CH:23]=1>C(Cl)Cl>[N:11]1[C:20]2[C:15](=[CH:16][CH:17]=[CH:18][CH:19]=2)[N:14]=[CH:13][C:12]=1[O:21][C:22]1[CH:33]=[CH:32][C:25]([O:26][CH:27]([CH3:31])[C:28]([O:4][CH2:1][CH:2]=[CH2:3])=[O:29])=[CH:24][CH:23]=1

Komponenten

5

Edukt 3

HCID 1049PyridineHCID 7858Allyl AlcoholHCID 136705322-[4-(2-Quinoxalinyloxy)phenoxy]propionyl chloride

Produkt 1

HCID 13670534Allyl 2-[4-(2-quinoxalinyloxy)phenoxy]propanoate

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel2×

Versuchsvorschrift

To a solution of 1.2 g allyl alcohol and 1.6 g pyridine in 50 cc methylene chloride, add 6.6 g of 2-[4-(2-quinoxalinyloxy)phenoxy]propionyl chloride in 60 cc methylene chloride. Stir the mixture at room temperature overnight. Wash the methylene chloride solution with water and dry the solution over magnesium sulfate concentrate under vacuum to give allyl 2-[4-(2-quinoxalinyloxy)phenoxy]propanoate.

Aufarbeitung

  1. washWash the methylene chloride solution with water
  2. dry with materialdry the solution over magnesium sulfate
  3. concentrationconcentrate under vacuum

Quellen und Nachweise

ORD-Eintrag
ord-a9135ae31a7f4357adf017005813a8cd
Quelldatensatz
uspto-grants-1986_09
Patentnummer
US04609396

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