(3-(tert-Butoxycarbonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)boronic acid → 1,1-Dimethylethyl 7-({2-cyano-4-[(methylamino)carbonyl]phenyl}oxy)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

HRID 645905

Reaktionsgleichung

Reaktionsgleichung von HRID 645905
[C:1]([C:3]1[CH:4]=[C:5]([CH:10]=[CH:11][C:12]=1[O:13]C1C=CC2CCN(C3CCC3)CCC=2C=1)[C:6]([NH:8][CH3:9])=[O:7])#[N:2].[CH3:29][C:30]([O:33][C:34]([N:36]1[CH2:42][CH2:41][C:40]2[CH:43]=[CH:44][C:45](B(O)O)=[CH:46][C:39]=2[CH2:38][CH2:37]1)=[O:35])([CH3:32])[CH3:31]>>[C:1]([C:3]1[CH:4]=[C:5]([C:6]([NH:8][CH3:9])=[O:7])[CH:10]=[CH:11][C:12]=1[O:13][C:45]1[CH:44]=[CH:43][C:40]2[CH2:41][CH2:42][N:36]([C:34]([O:33][C:30]([CH3:32])([CH3:31])[CH3:29])=[O:35])[CH2:37][CH2:38][C:39]=2[CH:46]=1)#[N:2]

Komponenten

3

Edukt 2

HCID 57440296(3-(tert-Butoxycarbonyl)-2,3,4,5-tetrahydro-1H-benzo[d]azepin-7-yl)boronic acidHCID 574403133-Cyano-4-[(3-cyclobutyl-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)oxy]-N-methylbenzamide

Produkt 1

HCID 685080391,1-Dimethylethyl 7-({2-cyano-4-[(methylamino)carbonyl]phenyl}oxy)-1,2,4,5-tetrahydro-3H-3-benzazepine-3-carboxylate

Versuchsvorschrift

The title compound was prepared from 3-cyano-4-hydroxy-N-methylbenzamide (E279, Step 3) and (3-{[(1,1-dimethylethyl)oxy]carbonyl}-2,3,4,5-tetrahydro-1H-3-benzazepin-7-yl)boronic acid (E264, Step 2), using the method of Example 264 Step 3; MS (ES+) m/e 322 [(M+H)—CO2tBu]+.

Quellen und Nachweise

ORD-Eintrag
ord-fbf47c5264cd42d381ddf95cc13433d5
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07704994B2

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