tert-butyl N-((4-hydroxypiperidin-4-yl)methyl)carbamate → Methyl 1-[(4-{[(tert-butoxycarbonyl)amino]methyl}-4-hydroxypiperidine-1-yl)methyl]cyclohexanecarboxylate

HRID 645984Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 645984
[OH:1][C:2]1([CH2:8][NH:9][C:10](=[O:16])[O:11][C:12]([CH3:15])([CH3:14])[CH3:13])[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.I[CH2:18][C:19]1([C:25]([O:27][CH3:28])=[O:26])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]1>>[C:12]([O:11][C:10]([NH:9][CH2:8][C:2]1([OH:1])[CH2:7][CH2:6][N:5]([CH2:18][C:19]2([C:25]([O:27][CH3:28])=[O:26])[CH2:24][CH2:23][CH2:22][CH2:21][CH2:20]2)[CH2:4][CH2:3]1)=[O:16])([CH3:13])([CH3:15])[CH3:14]

Komponenten

3

Edukt 2

HCID 10868112tert-butyl N-((4-hydroxypiperidin-4-yl)methyl)carbamateHCID 58947958Methyl 1-(iodomethyl)cyclohexanecarboxylate

Produkt 1

HCID 68584740Methyl 1-[(4-{[(tert-butoxycarbonyl)amino]methyl}-4-hydroxypiperidine-1-yl)methyl]cyclohexanecarboxylate

Versuchsvorschrift

The title compound was prepared by a method similar to that shown in the Step 2 of Example 3 by using tert-butyl [(4-hydroxypiperidin-4-yl)methyl]carbamate (Chem. Pharm. Bull., 2002, 50 (9) 1187-1194) and methyl 1-(iodomethyl)cyclohexanecarboxylate (Step 1 of Example 6).

Quellen und Nachweise

ORD-Eintrag
ord-00383ee843e24faf8ded3327460f0bc8
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07705020B2

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