Benzaldehyde → N-[2-(2-{[3-(4-chloro-phenyl)-2-hydroxy-3-methyl-4-oxo-cyclobut-1-enyl]-phenyl-methyl}-6-methyl-1H-indol-3-yl)-1,1-dimethyl-ethyl]-acetamide

HRID 646058Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 646058
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2([CH3:14])[C:11](=[O:12])[CH2:10][C:9]2=[O:13])=[CH:4][CH:3]=1.[CH:15](=O)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1.[CH3:23][C:24]([NH:37][C:38](=[O:40])[CH3:39])([CH3:36])[CH2:25][C:26]1[C:34]2[C:29](=[CH:30][C:31]([CH3:35])=[CH:32][CH:33]=2)[NH:28][CH:27]=1>>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2([CH3:14])[C:11](=[O:12])[C:10]([CH:15]([C:16]3[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=3)[C:27]3[NH:28][C:29]4[C:34]([C:26]=3[CH2:25][C:24]([NH:37][C:38](=[O:40])[CH3:39])([CH3:23])[CH3:36])=[CH:33][CH:32]=[C:31]([CH3:35])[CH:30]=4)=[C:9]2[OH:13])=[CH:6][CH:7]=1

Komponenten

4

Edukt 3

HCID 240BenzaldehydeHCID 685792552-(4-Chloro-phenyl)-2-methyl-cyclobutane-1,3-dioneHCID 68580747N-[1,1-dimethyl-2-(6-methyl-1H-indol-3-yl)-ethyl]-acetamide

Produkt 1

HCID 59264914N-[2-(2-{[3-(4-chloro-phenyl)-2-hydroxy-3-methyl-4-oxo-cyclobut-1-enyl]-phenyl-methyl}-6-methyl-1H-indol-3-yl)-1,1-dimethyl-ethyl]-acetamide

Versuchsvorschrift

Using general procedure C, 2-(4-chloro-phenyl)-2-methyl-cyclobutane-1,3-dione was reacted with benzaldehyde and N-[1,1-dimethyl-2-(6-methyl-1H-indol-3-yl)-ethyl]-acetamide (from Example 1.2) to give N-[2-(2-{[3-(4-chloro-phenyl)-2-hydroxy-3-methyl-4-oxo-cyclobut-1-enyl]-phenyl-methyl}-6-methyl-1H-indol-3-yl)-1,1-dimethyl-ethyl]-acetamide as a pale yellow solid. MS: 539.5 ([M−H]−).

Quellen und Nachweise

ORD-Eintrag
ord-c79e773d054045d18a8d398e6a0313db
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07705034B2

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