Hydrochloric Acid → 2-(4-Bromophenoxy)-2-methyl-1-(pyrrolidin-1-yl)propan-1-one

HRID 646124Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 646124
[NH:1]1[CH2:5][CH2:4][CH2:3][CH2:2]1.[Br:6][C:7]1[CH:19]=[CH:18][C:10]([O:11][C:12]([CH3:17])([CH3:16])[C:13](Cl)=[O:14])=[CH:9][CH:8]=1.Cl>CC#N.[Cl-].[Na+].O>[Br:6][C:7]1[CH:19]=[CH:18][C:10]([O:11][C:12]([CH3:16])([CH3:17])[C:13]([N:1]2[CH2:5][CH2:4][CH2:3][CH2:2]2)=[O:14])=[CH:9][CH:8]=1

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 31268PyrrolidineHCID 45923264HCID 45923264, Verbindung

Produkt 1

HCID 686947812-(4-Bromophenoxy)-2-methyl-1-(pyrrolidin-1-yl)propan-1-oneAusbeute 94,3 %

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 6342AcetonitrileLösungsmittel2×HCID 57417360Sodium chloride; waterLösungsmittel

Versuchsvorschrift

Pyrrolidine (1.54 g, 21.6 mmol) in anhydrous MeCN (10 mL) was added with stirring to 2-(4-bromophenoxy)-2-methylpropanoyl chloride (2 g, 7.2 mmol) in anhydrous MeCN (10 mL) at 0° C. The mixture was stirred at room temperature for 18 h and acidified with HCl (aq. 1M, 40 mL). Brine was added and the mixture was extracted with CH2Cl2. The combined extracts were washed with NaHCO3 (aq. sat) and brine, dried (Na2SO4), and concentrated to give the sub-title compound (2.12 g, 94%).

Aufarbeitung

  1. extractionthe mixture was extracted with CH2Cl2
  2. washThe combined extracts were washed with NaHCO3 (aq. sat) and brine
  3. dry with materialdried (Na2SO4)
  4. concentrationconcentrated

Quellen und Nachweise

ORD-Eintrag
ord-1a2c603c73604cefa9e76b385285ffd3
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07705023B2

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