Hydrochloric Acid → 4-(4-trifluoromethoxyphenyl)benzylamine Hydrochloride

HRID 646198Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 646198
[F:1][C:2]([F:19])([F:18])[O:3][C:4]1[CH:9]=[CH:8][C:7]([C:10]2[CH:15]=[CH:14][C:13]([C:16]#[N:17])=[CH:12][CH:11]=2)=[CH:6][CH:5]=1.FC(F)(F)OC1C=CC(B(O)O)=CC=1.[ClH:34]>C(O)C.[OH-].[OH-].[Pd+2]>[ClH:34].[F:1][C:2]([F:18])([F:19])[O:3][C:4]1[CH:5]=[CH:6][C:7]([C:10]2[CH:15]=[CH:14][C:13]([CH2:16][NH2:17])=[CH:12][CH:11]=2)=[CH:8][CH:9]=1

Komponenten

6

Edukt 3

HCID 313Hydrochloric AcidHCID 27343864-(Trifluoromethoxy)phenylboronic acidHCID 214636134-[4-(Trifluoromethoxy)phenyl]benzonitrile

Produkt 1

HCID 229284574-(4-trifluoromethoxyphenyl)benzylamine Hydrochloride

Reagenzien, Katalysatoren, Lösungsmittel 2

HCID 9942167Palladium hydroxideKatalysatorHCID 702EthanolLösungsmittel

Versuchsvorschrift

A solution of 4′-[(trifluoromethyl)oxy]-4-biphenylcarbonitrile (prepared from {4-[(trifluoromethyl)oxy]phenyl}boronic acid by a method analogous to that described for the 4′-trifluoromethyl analogue, Intermediate D6 of WO 02/30911) (66.6 g) in ethanol (2000 ml) and concentrated hydrochloric acid (100 ml) was hydrogenated over Pearlman's catalyst (10 g) at 25 psi until reduction was complete. The catalyst was removed by filtration through celite, then the solvent was removed in vacuo to obtain the desired product.

Aufarbeitung

  1. customThe catalyst was removed by filtration through celite
  2. customthe solvent was removed in vacuo

Quellen und Nachweise

ORD-Eintrag
ord-b70ee73268ff4c93a052b690c6a528e2
Quelldatensatz
uspto-grants-2010_04
Patentnummer
US07705005B2

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