4-Methylthiophene-2-boronic acid → [4-(4-Methyl-thiophen-2-yl)-phenyl]-((S)-2-pyrrolidin-1-ylmethyl-pyrrolidin-1-yl)-methanone
Reaktionsgleichung
[CH3:1][C:2]1[CH:3]=[C:4](B(O)O)[S:5][CH:6]=1.[N:10]1([CH2:15][CH:16]2[CH2:20][CH2:19][CH2:18][N:17]2[C:21]([C:23]2[CH:28]=[CH:27][C:26](Br)=[CH:25][CH:24]=2)=[O:22])[CH2:14][CH2:13][CH2:12][CH2:11]1>>[CH3:1][C:2]1[CH:3]=[C:4]([C:26]2[CH:27]=[CH:28][C:23]([C:21]([N:17]3[CH2:18][CH2:19][CH2:20][C@H:16]3[CH2:15][N:10]3[CH2:11][CH2:12][CH2:13][CH2:14]3)=[O:22])=[CH:24][CH:25]=2)[S:5][CH:6]=1Komponenten
3
Versuchsvorschrift
The title compound is prepared in a manner substantially analogous to Procedure Q starting from 4-Methyl-2-thiophene boronic acid and 4-(2-Pyrrolidin-1-ylmethyl-pyrrolidine-1-carbonyl)-phenyl bromide to give 70 mg (67%). MS (ES+) 355.2
Aufarbeitung
- customto give 70 mg (67%)