1,2-Dibromoethane → 2-[2,6-Dichloro-4-(2,2,2-trifluoroethylthio)-phenoxy]-ethyl bromide

HRID 64648

Reaktionsgleichung

[Na].[Cl:2][C:3]1[CH:8]=[C:7]([S:9][CH2:10][C:11]([F:14])([F:13])[F:12])[CH:6]=[C:5]([Cl:15])[C:4]=1[OH:16].[CH2:17](Br)[CH2:18][Br:19]>C(O)C>[Cl:15][C:5]1[CH:6]=[C:7]([S:9][CH2:10][C:11]([F:13])([F:14])[F:12])[CH:8]=[C:3]([Cl:2])[C:4]=1[O:16][CH2:17][CH2:18][Br:19]

Komponenten

Reaktionsbedingungen

Temperatur: 40 °C

Versuchsvorschrift

To an ethanol solution of sodium ethylate obtained by dissolving 0.7 g of metallic sodium in 50 ml of ethanol were added 8.9 g of 2,6-dichloro-4-(2,2,2-trifluoroethylthio)-phenol and 20 g of ethylene bromide. The mixture was stirred at 40° C. for 2 hours and under reflux for 4 hours. Ethanol and the excess of ethylene bromide were evaporated. The residue was taken into 150 ml of toluene, washed with a 5% aqueous solution of potassium hydroxide and water in this sequence, and dried over anhydrous sodium sulfate. Toluene was evaporated, and the residue was distilled under reduced pressure to give 7.2 g of 2-[2,6-dichloro-4-(2,2,2-trifluoroethylthio)-phenoxy]-ethyl bromide with the b.p.=124°-126° C./0.8 mmHg.

Aufarbeitung

temperatureunder reflux for 4 hours
customEthanol and the excess of ethylene bromide were evaporated
washwashed with a 5% aqueous solution of potassium hydroxide and water in this sequence
dry with materialdried over anhydrous sodium sulfate
customToluene was evaporated
distillationthe residue was distilled under reduced pressure

Quellen und Nachweise

ORD-Eintrag: ord-ea7863179ebd4bd8baa5658f7a499e8f
Quelldatensatz: uspto-grants-1986_09
DOI: 10.6084/m9.figshare.5104873.v1
Patentnummer: US04609669

Verknüpfte Notizen

Wird geladen…