Ethanol → HCID 178467003, Verbindung
Reaktionsgleichung
[Br:1][C:2]1[C:7]([NH2:8])=[CH:6][CH:5]=[CH:4][C:3]=1[O:9][CH3:10].[CH2:11]([OH:13])[CH3:12]>>[CH2:11]([O:13][C:7]1[CH:2]=[C:3]([OH:9])[C:6]2[C:7](=[C:2]([Br:1])[C:3]([O:9][CH3:10])=[CH:4][CH:5]=2)[N:8]=1)[CH3:12]Komponenten
3
Versuchsvorschrift
To 2-bromo-3-aminoanisole 2b4 (750 mg, 3.7 mmol, 1 eq) was added imidate 2g2 (0.73 g, 3.7 mmol, 1 eq) in ethanol (7 mL) under a N2 atmosphere. The mixture was stirred at RT. for 24 hrs at which point the reaction was concentrated and purified directly on a silica gel column (eluent: EtOAc/Hexanes (1:9)) to afford adduct 2o1 (1.12 g, 88%) as a pale yellow oil. MS: 344 (M+H)+ and 346 (MH+2)+.
Aufarbeitung
- concentrationthe reaction was concentrated
- custompurified directly on a silica gel column (eluent: EtOAc/Hexanes (1:9))
- customto afford adduct 2o1 (1.12 g, 88%) as a pale yellow oil
Quellen und Nachweise
- ORD-Eintrag
- ord-3da86e45c59148e7b6b06f0e59ca1225
- Quelldatensatz
- uspto-grants-2010_04
- Patentnummer
- US07705146B2
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