3-(1-oxo-4-ethoxycarbonylbutyl)-N-(3-pyridyl)indole → 3-(1-oxo-4-carboxybutyl)-N-(3-pyridyl)-indole

HRID 64679Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 64679
[O:1]=[C:2]([C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]([C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)[CH:12]=1)[CH2:3][CH2:4][CH2:5][C:6]([O:8]CC)=[O:7]>[OH-].[Na+]>[O:1]=[C:2]([C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]([C:20]2[CH:21]=[N:22][CH:23]=[CH:24][CH:25]=2)[CH:12]=1)[CH2:3][CH2:4][CH2:5][C:6]([OH:8])=[O:7]

Komponenten

3

Edukt 1

HCID 136726963-(1-oxo-4-ethoxycarbonylbutyl)-N-(3-pyridyl)indole

Produkt 1

HCID 136726973-(1-oxo-4-carboxybutyl)-N-(3-pyridyl)-indole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 14798Sodium HydroxideLösungsmittel

Versuchsvorschrift

A mixture of 15.0 of 3-(1-oxo-4-ethoxycarbonylbutyl)-N-(3-pyridyl)indole, 100 ml of 0.5N sodium hydroxide is heated under reflux for 16 hours. The solution is acidified to pH of about 6 with hydrochloric and extracted with methylene chloride. The methylene chloride extract is dried over sodium sulfate and evaporated to dryness to give 3-(1-oxo-4-carboxybutyl)-N-(3-pyridyl)-indole, melting point 177°-178°.

Aufarbeitung

  1. temperatureis heated
  2. temperatureunder reflux for 16 hours
  3. extractionextracted with methylene chloride
  4. extractionThe methylene chloride extract
  5. dry with materialis dried over sodium sulfate
  6. customevaporated to dryness

Quellen und Nachweise

ORD-Eintrag
ord-bac6c13fde434d098a681ccd1fde0d81
Quelldatensatz
uspto-grants-1986_09
Patentnummer
US04609733

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