Thionyl Chloride → 6,6-Difluorohex-5-enoic acid chloride
Reaktionsgleichung
S(Cl)([Cl:3])=O.[F:5][C:6]([F:14])=[CH:7][CH2:8][CH2:9][CH2:10][C:11](O)=[O:12]>CN(C)C=O>[F:5][C:6]([F:14])=[CH:7][CH2:8][CH2:9][CH2:10][C:11]([Cl:3])=[O:12]Komponenten
4
Edukt 2
Produkt 1
Reagenzien, Katalysatoren, Lösungsmittel 1
Versuchsvorschrift
10.23 ml (140.68 mmol) Thionyl chloride was added dropwise to 8.0 g (52.29 mmol) of the product of Example 9 at room temperature. A drop of dimethylformamide was added and the mixture heated under reflux for 6 hours. It was then distilled under reduced pressure.
Aufarbeitung
- temperaturethe mixture heated
- temperatureunder reflux for 6 hours
- distillationIt was then distilled under reduced pressure
Quellen und Nachweise
- ORD-Eintrag
- ord-d30cf53005b044ea9db9fca6b67dce41
- Quelldatensatz
- uspto-grants-1993_09
- Patentnummer
- US05248810
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