HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Potassium Carbonate → 4-[4-(2-Chloro-4-trifluoromethylphenoxy)phenoxy]-3-methoxy-2-pentenoic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Potassium Carbonate | HCID 11430 | — |
| Edukt | 4-[2-Chloro-4-(trifluoromethyl)phenoxy]phenol | HCID 12940613 | — |
| Edukt | Methyl 4-bromo-3-methoxypent-2-enoate | HCID 54279858 | — |
| Lösungsmittel | Acetone | HCID 180 | — |
| Produkt | 4-[4-(2-Chloro-4-trifluoromethylphenoxy)phenoxy]-3-methoxy-2-pentenoic acid | HCID 53860348 | — |
Reaktionsschritte
A mixture of 4-(2-chloro-4-trifluoromethylphenoxy) phenol (6.9 mmol.), methyl 4-bromo-3-methoxy-2-pentenoate (8.9 mmol.) and potassium carbonate (1.5 equis.) in acetone (15 ml.) is refluxed for 48 hours. After filtration, the filtrate was concentrated and the residue chromatographed on silica gel using 20% ethylacetate/hexane to give the methyl ester of 4-[4-(2-chloro-4-trifluoromethylphenoxy)phenoxy]-3-methoxy-2-pentenoic acid.
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04408076 |
| Quelldatensatz | uspto-grants-1983_10 |
| ORD ID | ord-493aa7b9e12743a5bfd74929eaef950c |
| Quellennotiz | uspto-grants-1983_10 |