Acetyl chloride → N-{[3-(2-Phenylethyl)pyridin-2-yl]methyl}acetamide

HRID 647504Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 647504
[C:1](Cl)(=[O:3])[CH3:2].[NH2:5][CH2:6][C:7]1[C:12]([CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:11][CH:10]=[CH:9][N:8]=1.C(N(CC)CC)C>C1COCC1>[C:1]([NH:5][CH2:6][C:7]1[C:12]([CH2:13][CH2:14][C:15]2[CH:20]=[CH:19][CH:18]=[CH:17][CH:16]=2)=[CH:11][CH:10]=[CH:9][N:8]=1)(=[O:3])[CH3:2]

Komponenten

5

Edukt 3

HCID 6367Acetyl chlorideHCID 8471TriethylamineHCID 20485150HCID 20485150, Verbindung

Produkt 1

HCID 20485147N-{[3-(2-Phenylethyl)pyridin-2-yl]methyl}acetamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

Add dropwise with stirring a solution of 1.24 gm acetyl chloride in 10 ml THF to a cooled solution of 3.2 gm of 2-aminomethyl-3-(2-phenylethyl)pyridine and 2.3 ml triethylamine in 100 ml THF. Warm the reaction mixture to room temperature and then stir for an additional 0.5 hour. Filter off the triethylamine hydrochloride and evaporate the filtrate under reduced pressure. Chromatograph on silica gel using 40% THF in chloroform to obtain 2-acetamidomethyl-3-(2-phenylethyl)pyridine.

Aufarbeitung

  1. additionAdd dropwise
  2. filtrationFilter off the triethylamine hydrochloride
  3. customevaporate the filtrate under reduced pressure

Quellen und Nachweise

ORD-Eintrag
ord-79e05b060aae480e9679c512c85c0cac
Quelldatensatz
uspto-grants-1983_10
Patentnummer
US04409226

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