Ammonia → 3-[N-{2-nitro-5-(2-chloro-4-methylsulphonylphenoxy)phenyl}amino]propionamide

HRID 64758Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 64758
[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[CH:16]=[CH:15][C:14]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:13][C:12]=2[Cl:21])=[CH:6][C:5]=1[NH:22][CH2:23][CH2:24][C:25]([O:27]C)=O)([O-:3])=[O:2].[NH3:29]>CO>[N+:1]([C:4]1[CH:9]=[CH:8][C:7]([O:10][C:11]2[CH:16]=[CH:15][C:14]([S:17]([CH3:20])(=[O:19])=[O:18])=[CH:13][C:12]=2[Cl:21])=[CH:6][C:5]=1[NH:22][CH2:23][CH2:24][C:25]([NH2:29])=[O:27])([O-:3])=[O:2]

Komponenten

4

Edukt 2

HCID 222AmmoniaHCID 20237335methyl 3-[N-{2-nitro-5-(2-chloro-4-methylsulphonylphenoxy)phenyl}amino]propionate

Produkt 1

HCID 202373603-[N-{2-nitro-5-(2-chloro-4-methylsulphonylphenoxy)phenyl}amino]propionamide

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 887MethanolLösungsmittel

Versuchsvorschrift

The ester (7), obtained according to Example III, in an amount of 1.6 g was suspended in 40 ml of methanol. Ammonia was introduced until saturation and then the reaction mixture was stirred for two days. The solid material was sucked off and recrystallized from ethylacetate. The desired product was obtained in a yield of 0.9 g; melting point 196° C.

Aufarbeitung

  1. customrecrystallized from ethylacetate

Quellen und Nachweise

ORD-Eintrag
ord-cf111e7778574e5380b809ac092446f2
Quelldatensatz
uspto-grants-1986_09
Patentnummer
US04609753

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