DL-leucine → L-leucine N-carbobenzoxy-L-aspartic acid

Beteiligte Stoffe

Reaktionsbedingungen

Reaktionsschritte

Ten grams of DL-leucine, 12.2 g of N-carbobenzoxy-L-aspartic acid and 1.9 g of sulfuric acid were added to 500 ml of water and the resulting solution was heated to 60° C. This solution was cooled to 10° C. at a rate of 2° C. per hour while stirring, and was stirred for another two hours. The resulting crystal was separated, washed with 30 ml of water and dried to give 9.1 g of an L-leucine/N-carbobenzoxy-L-aspartic acid. Analysis showed that the optical purity of the L-leucine was 95%.

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