1-Sec-butyl-piperidin-4-one → 9-Sec.-butyl-1-methyl-7,8,9,10-tetrahydrothieno[3,2-e]pyrido[4,3-b]indole

HRID 647936Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 647936
Cl.[NH:2]([C:4]1[CH:5]=[CH:6][C:7]2[S:11][CH:10]=[C:9]([CH3:12])[C:8]=2[CH:13]=1)N.[CH:14]([N:18]1[CH2:23][CH2:22][C:21](=O)[CH2:20][CH2:19]1)([CH2:16][CH3:17])[CH3:15].C(O)(C)C.Cl>C(O)(C)C>[CH:14]([N:18]1[CH2:23][CH2:22][C:21]2[NH:2][C:4]3[C:13]([C:20]=2[CH2:19]1)=[C:8]1[C:9]([CH3:12])=[CH:10][S:11][C:7]1=[CH:6][CH:5]=3)([CH2:16][CH3:17])[CH3:15]

Komponenten

5

Edukt 3

HCID 131828071-Sec-butyl-piperidin-4-oneHCID 204843225-Hydrazino-3-methylbenzothiophene hydrochlorideHCID 21912024Isopropanol hydrochloride

Produkt 1

HCID 204842929-Sec.-butyl-1-methyl-7,8,9,10-tetrahydrothieno[3,2-e]pyrido[4,3-b]indole

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 3776IsopropanolLösungsmittel

Versuchsvorschrift

11 g of 5-hydrazino-3-methylbenzothiophene hydrochloride and 8.5 g of 1-sec.-butyl-4-piperidone are boiled in 35 ml of isopropanol, and during this procedure isopropanol/HCl are added dropwise. The mixture is then evaporated, the residue is taken up in water and the mixture is rendered alkaline and extracted with methylene chloride. After washing and drying the organic phase, it is evaporated and the residue is recrystallised from cyclohexane. Melting point: 136°-137° C.

Aufarbeitung

  1. customThe mixture is then evaporated
  2. extractionextracted with methylene chloride
  3. washAfter washing
  4. customdrying the organic phase, it
  5. customis evaporated
  6. customthe residue is recrystallised from cyclohexane

Quellen und Nachweise

ORD-Eintrag
ord-df7cf8c6b553416f8d8f5dedd3a353ab
Quelldatensatz
uspto-grants-1983_10
Patentnummer
US04410536

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