Benzoyl chloride → HCID 20145253, Verbindung

HRID 648641Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 648641
[C:1](Cl)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[NH2:10][C:11]1[CH:12]=[CH:13][C:14]([N:32]2[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]2)=[C:15]([CH:17]([CH:19]([C:29]([NH2:31])=[O:30])[C:20]2[CH:28]=[CH:27][C:23]([C:24]([OH:26])=[O:25])=[CH:22][CH:21]=2)[CH3:18])[CH:16]=1.C(N(CC)CC)C>CN(C)C=O>[C:1]([NH:10][C:11]1[CH:12]=[CH:13][C:14]([N:32]2[CH2:37][CH2:36][CH2:35][CH2:34][CH2:33]2)=[C:15]([CH:17]([CH:19]([C:29]([NH2:31])=[O:30])[C:20]2[CH:28]=[CH:27][C:23]([C:24]([OH:26])=[O:25])=[CH:22][CH:21]=2)[CH3:18])[CH:16]=1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Komponenten

5

Edukt 3

HCID 7412Benzoyl chlorideHCID 8471TriethylamineHCID 20145241HCID 20145241, Verbindung

Produkt 1

HCID 20145253HCID 20145253, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

An amount of 0.30 ml (2.62 m mol) of benzoyl chloride was added dropwise to a solution of 1 gm (2.62 m mol) of 4-[(1-(5-amino-2-piperidino-phenyl)-ethyl)-aminocarbonylmethyl]-benzoic acid and of 0.37 ml (2.62 m mol) of triethylamine in 10 ml of anhydrous dimethyl formamide. After stirring for two hours at 20° to 30° C., the reaction mixture was evaporated in vacuo and distributed between water and ethyl acetate. The organic phase was dried, filtered, and evaporated in vacuo. The evaporation residue (1.12 gm) was recrystallized from ethanol by addition of activated charcoal.

Aufarbeitung

  1. customthe reaction mixture was evaporated in vacuo
  2. customThe organic phase was dried
  3. filtrationfiltered
  4. customevaporated in vacuo
  5. customThe evaporation residue (1.12 gm) was recrystallized from ethanol by addition of activated charcoal

Quellen und Nachweise

ORD-Eintrag
ord-17f02ebd966d463e845530d2aa1aef43
Quelldatensatz
uspto-grants-1988_04
Patentnummer
US04735959

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