Phosphorus oxychloride → 2-Chloro-4-(4-fluorobenzoyl)-pyridine

HRID 648717

Reaktionsgleichung

Reaktionsgleichung von HRID 648717
[F:1][C:2]1[CH:16]=[CH:15][C:5]([C:6]([C:8]2[CH:13]=[CH:12][N+:11]([O-])=[CH:10][CH:9]=2)=[O:7])=[CH:4][CH:3]=1.O=P(Cl)(Cl)[Cl:19]>>[Cl:19][C:12]1[CH:13]=[C:8]([C:6](=[O:7])[C:5]2[CH:15]=[CH:16][C:2]([F:1])=[CH:3][CH:4]=2)[CH:9]=[CH:10][N:11]=1

Komponenten

3

Edukt 2

HCID 24813Phosphorus oxychlorideHCID 541432034-(4-fluorobenzoyl)-pyridine N-oxide

Produkt 1

HCID 201457102-Chloro-4-(4-fluorobenzoyl)-pyridine

Versuchsvorschrift

0.88 g 4-(4-fluorobenzoyl)-pyridine N-oxide and 50 ml POCl3 are refluxed for 2 hrs. Excess POCl3 is distilled at normal pressure. The crude is treated with slightly alkaline cold water and then extracted with methylene chloride. Working as usual affords 0.80 g of title product, identical with that obtained by the Friedel-Crafts process (see Ex. 3d).

Aufarbeitung

  1. distillationExcess POCl3 is distilled at normal pressure
  2. additionThe crude is treated with slightly alkaline cold water
  3. extractionextracted with methylene chloride

Quellen und Nachweise

ORD-Eintrag
ord-297ae98322534e3db5a0a6253499a89f
Quelldatensatz
uspto-grants-1988_04
Patentnummer
US04736037

Verknüpfte Notizen

Wird geladen…