1-Iodopropane → 3-Methoxy-2-methyl-4-propoxypyridine

HRID 649208

Reaktionsgleichung

Reaktionsgleichung von HRID 649208
[CH3:1][O:2][C:3]1[C:8](=[O:9])[CH:7]=[CH:6][NH:5][C:4]=1[CH3:10].[CH2:11](I)[CH2:12][CH3:13]>CN(C)C=O.C(Cl)(Cl)Cl.[Ag]=O>[CH3:1][O:2][C:3]1[C:4]([CH3:10])=[N:5][CH:6]=[CH:7][C:8]=1[O:9][CH2:11][CH2:12][CH3:13]

Komponenten

6

Edukt 2

HCID 336431-IodopropaneHCID 3234243-Methoxy-2-methyl-1H-pyridin-4-one

Produkt 1

HCID 139829483-Methoxy-2-methyl-4-propoxypyridine

Reagenzien, Katalysatoren, Lösungsmittel 3

HCID 92152Silver(II) oxideKatalysatorHCID 6212ChloroformLösungsmittelHCID 6228DimethylformamideLösungsmittel

Versuchsvorschrift

3-Methoxy-2-methyl-4(1H)-pyridone(1.39 g) and propyl iodide (2.0 ml) were dissolved in dimethylformamide (20 ml), to which silver oxide (2.31 g) was added in small portions and stirred vigorously at room temperature for 5 hours. The reaction mixture was diluted with chloroform (100 ml), washed with water, dried and evaporated. The residue was purified by flash chromatography (chloroform) on silica gel, to give 3-methoxy-2-methyl-4-propoxypyridine (1.7 g) as a light brown oil.

Aufarbeitung

  1. additionwas added in small portions
  2. washwashed with water
  3. customdried
  4. customevaporated
  5. customThe residue was purified by flash chromatography (chloroform) on silica gel

Quellen und Nachweise

ORD-Eintrag
ord-2a493dc1dce0447e91aa00ee831790d4
Quelldatensatz
uspto-grants-1988_04
Patentnummer
US04738975

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