HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Methyl Isocyanate → N-(4-benzyloxybenzyl)-O-methylcarbamoylacetohydroxamic acid
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Methyl Isocyanate | HCID 12228 | — |
| Edukt | N-(4-benzyloxybenzyl)acetohydroxamic acid | HCID 129265 | — |
| Katalysator | 1,8-Diazabicyclo(5.4.0)undec-7-ene | HCID 81184 | — |
| Lösungsmittel | Tetrahydrofuran | HCID 8028 | — |
| Produkt | N-(4-benzyloxybenzyl)-O-methylcarbamoylacetohydroxamic acid | HCID 15670601 | 82,6% |
Reaktionsschritte
A mixture of N-(4-benzyloxybenzyl)acetohydroxamic acid (1.35 g), methyl isocyanate (0.65 g) and 1,8-diazabicyclo [5.4.0] undec-7-ene catalyst (1 drop) in tetrahydrofuran (10 ml) was stirred for 3 hours then left overnight to provide N-(4-benzyloxybenzyl)-O-methylcarbamoylacetohydroxamic acid (1.35 g) m.pt. 101°-102° [from ethyl acetate-light petroleum (b.pt. 60°-80°)].
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US04738986 |
| Quelldatensatz | uspto-grants-1988_04 |
| ORD ID | ord-6747b1aa6fce4339aea10ea0c4c4e662 |
| Quellennotiz | uspto-grants-1988_04 |