Triethylamine → Phosphoramidic dichloride, bis(2-chloroethyl)-

HRID 649337

Reaktionsgleichung

Reaktionsgleichung von HRID 649337
[P:1]([Cl:5])(Cl)([Cl:3])=[O:2].[Cl:6][CH2:7][CH2:8][NH:9][CH2:10][CH2:11][Cl:12].C(N(CC)CC)C.Cl.C(N(CC)CC)C>C1COCC1>[Cl:6][CH2:7][CH2:8][N:9]([CH2:10][CH2:11][Cl:12])[P:1]([Cl:5])([Cl:3])=[O:2]

Komponenten

6

Edukt 4

HCID 8471TriethylamineHCID 9533Bis(2-chloroethyl)amineHCID 11130Triethylamine hydrochlorideHCID 24813Phosphorus oxychloride

Produkt 1

HCID 96271Phosphoramidic dichloride, bis(2-chloroethyl)-

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel2×

Versuchsvorschrift

Phosphorous oxychloride (0.15 mol) in 100 ml. THF are mixed dropwise at 10° C. with bis-chloroethylamine (0.1 mol) in 100 ml. THF and triethylamine (0.15 mol). After ending of the reaction (TLC verification), triethylamine hydrochloride is filtered off and the filtrate, after the addition of 50 ml. toluene, evaporated. The oily residue is immediately further reacted.

Aufarbeitung

  1. filtrationis filtered off
  2. additionthe filtrate, after the addition of 50 ml
  3. customtoluene, evaporated
  4. customThe oily residue is immediately further reacted

Quellen und Nachweise

ORD-Eintrag
ord-c0af85cf54a442ee855b99cb32b2c48a
Quelldatensatz
uspto-grants-1988_04
Patentnummer
US04739095

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