2-Thiophenecarboxylic acid, 3-(isocyanatosulfonyl)-, methyl ester → 3-[[(4-Cyano-6-methoxypyrimidin-2-yl)aminocarbonyl]aminosulfonyl]-2-thiophenecarboxylic acid, methyl ester

HRID 649438Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 649438
[NH2:1][C:2]1[N:7]=[C:6]([C:8]#[N:9])[CH:5]=[C:4]([O:10][CH3:11])[N:3]=1.[C:12]([C:16]1[S:17][CH:18]=[CH:19][C:20]=1[S:21]([N:24]=[C:25]=[O:26])(=[O:23])=[O:22])([O:14][CH3:15])=[O:13]>C(Cl)Cl>[C:8]([C:6]1[CH:5]=[C:4]([O:10][CH3:11])[N:3]=[C:2]([NH:1][C:25]([NH:24][S:21]([C:20]2[CH:19]=[CH:18][S:17][C:16]=2[C:12]([O:14][CH3:15])=[O:13])(=[O:22])=[O:23])=[O:26])[N:7]=1)#[N:9]

Komponenten

4

Edukt 2

HCID 1572962-Thiophenecarboxylic acid, 3-(isocyanatosulfonyl)-, methyl esterHCID 141292502-Amino-6-methoxypyrimidine-4-carbonitrile

Produkt 1

HCID 141292513-[[(4-Cyano-6-methoxypyrimidin-2-yl)aminocarbonyl]aminosulfonyl]-2-thiophenecarboxylic acid, methyl ester

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 6344DichloromethaneLösungsmittel

Versuchsvorschrift

2-Amino-4-cyano-6-methoxypyrimidine, 0.1 g, was mixed with 2-carbomethoxythiophene-3-sulfonyl isocyanate, 0.165 g, in 10 ml of methylene chloride. The reaction mixture was stirred at room temperature overnight. The reaction mixture was stripped to yield 0.19 g of the title compound as a solid, m.p. 89°-92° C. (dec). NMR (CDCl3): δ6.89 (s, 3H), 4.20 (s, 3H), 6.83 (s, 1H), 7.59 (d, 1H), 7.80 (d, 1H).

Quellen und Nachweise

ORD-Eintrag
ord-d474613647f64916ae1c47abf4f4ae76
Quelldatensatz
uspto-grants-1988_04
Patentnummer
US04740229

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