Triphenylphosphine → HCID 57238973, Verbindung

HRID 650583Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 650583
[CH3:1][C:2]1[C:3]([CH:16]([OH:18])[CH3:17])=[CH:4][C:5]2[C:6]([CH3:15])([CH3:14])[CH2:7][CH2:8][C:9]([CH3:13])([CH3:12])[C:10]=2[CH:11]=1.C1(P(C2C=CC=CC=2)C2C=CC=CC=2)C=CC=CC=1.N(C(OCC)=O)=NC(OCC)=O.[CH3:50][O:51][C:52](=[O:77])[C@@H:53]([NH:62][C:63]1[CH:68]=[CH:67][CH:66]=[CH:65][C:64]=1[C:69](=[O:76])[C:70]1[CH:75]=[CH:74][CH:73]=[CH:72][CH:71]=1)[CH2:54][C:55]1[CH:60]=[CH:59][C:58](O)=[CH:57][CH:56]=1>C1COCC1>[CH3:50][O:51][C:52](=[O:77])[C@@H:53]([NH:62][C:63]1[CH:68]=[CH:67][CH:66]=[CH:65][C:64]=1[C:69](=[O:76])[C:70]1[CH:75]=[CH:74][CH:73]=[CH:72][CH:71]=1)[CH2:54][C:55]1[CH:56]=[CH:57][C:58]([O:18][CH:16]([C:3]2[C:2]([CH3:1])=[CH:11][C:10]3[C:9]([CH3:13])([CH3:12])[CH2:8][CH2:7][C:6]([CH3:15])([CH3:14])[C:5]=3[CH:4]=2)[CH3:17])=[CH:59][CH:60]=1

Komponenten

6

Edukt 4

HCID 11776TriphenylphosphineHCID 220568ethyl N-ethoxycarbonyliminocarbamateHCID 49833401-(3,5,5,8,8-Pentamethyl-5,6,7,8-tetrahydro-naphthalen-2-yl)-ethanolHCID 10667178N-(2-benzoylphenyl)tyrosine methyl ester

Produkt 1

HCID 57238973HCID 57238973, Verbindung

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 8028TetrahydrofuranLösungsmittel

Versuchsvorschrift

A solution of 1-(3,5,5,8,8-pentamethyl-5,6,7,8-tetrahydronaphthalen-2-yl)-ethanol (184 mg; 0.75 mmol), triphenylphosphine (268 mg; 1.0 mmol), diethyl azodicarboxylate (0.161 ml; 1.0 mmol) and (2S)-2-((2-benzoylphenyl)amino)-3-(4-hydroxyphenyl)-propionic acid methyl ester (190 mg; 0.5 mmol) in THF (10 ml) was stirred at 0° C. for 1.5 hours and for 16 hours at room temperature. The reaction mixture was evaporated and the residue was purified on column chromatography using methylene chloride as eluent. Yield 118 mg.

Aufarbeitung

  1. customThe reaction mixture was evaporated
  2. customthe residue was purified on column chromatography

Quellen und Nachweise

ORD-Eintrag
ord-e57f933e14b74c98ab4c86b7bdb57da5
Quelldatensatz
uspto-grants-2001_08
Patentnummer
US06274608B1

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