Phosgene → N-Propyl-N-(tetrahydrofuran-3-yl)carbamoyl chloride

HRID 650878Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 650878
[C:1]([Cl:4])(Cl)=[O:2].[CH2:5]([NH:8][CH:9]1[CH2:13][CH2:12][O:11][CH2:10]1)[CH2:6][CH3:7].C(N(CC)CC)C>>[CH2:5]([N:8]([CH:9]1[CH2:13][CH2:12][O:11][CH2:10]1)[C:1]([Cl:4])=[O:2])[CH2:6][CH3:7]

Komponenten

4

Edukt 3

HCID 6371PhosgeneHCID 8471TriethylamineHCID 21709909N-Propyl-N-(tetrahydrofuran-3-yl)amine

Produkt 1

HCID 21709911N-Propyl-N-(tetrahydrofuran-3-yl)carbamoyl chloride

Versuchsvorschrift

94 g (0.95 mol) of phosgene, 41 g (0.32 mol) of N-propyl-N-(tetrahydrofuran-3-yl)amine and 32 g (0.32 mol) of triethylamine were reacted by the method of the process described in Intermediate 1.2. Yield 54 g. 1H NMR (270 MHz, in CDCl3): δ=0.92 (t, 3H), 1.70 (sext., 2H), 2.02 (s, 1H), 2.30 (s, 1H), 3.20-3.40 (m, 2H), 3.65-3.85 (m, 3H), 4.05 (m, 1H), 4.50-4.70 and 4.85-5.05 (2 m, together 1H).

Quellen und Nachweise

ORD-Eintrag
ord-5964de82f91b47fe904d835b244817db
Quelldatensatz
uspto-grants-2001_08
Patentnummer
US06277790B1

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